Sox17 is indispensable for acquisition and maintenance of arterial identity
Identifieur interne : 003146 ( Main/Exploration ); précédent : 003145; suivant : 003147Sox17 is indispensable for acquisition and maintenance of arterial identity
Auteurs : Monica Corada [Italie] ; Fabrizio Orsenigo [Italie] ; Marco Francesco Morini [Italie] ; Mara Elena Pitulescu [Allemagne] ; Ganesh Bhat [Italie] ; Daniel Nyqvist [Suède] ; Ferruccio Breviario [Italie] ; Valentina Conti [Italie] ; Anais Briot [États-Unis] ; M. Luisa Iruela-Arispe [États-Unis] ; Ralf H. Adams [Allemagne] ; Elisabetta Dejana [Italie]Source :
- Nature Communications [ 2041-1723 ] ; 2013.
Abstract
The functional diversity of the arterial and venous endothelia is regulated through a complex system of signalling pathways and downstream transcription factors. Here we report that the transcription factor Sox17, which is known as a regulator of endoderm and hemopoietic differentiation, is selectively expressed in arteries, and not in veins, in the mouse embryo and in mouse postnatal retina and adult. Endothelial cell-specific inactivation of Sox17 in the mouse embryo is accompanied by a lack of arterial differentiation and vascular remodelling that results in embryo death
Url:
DOI: 10.1038/ncomms3609
PubMed: 24153254
PubMed Central: 3826640
Affiliations:
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first="Fabrizio" last="Orsenigo">Fabrizio Orsenigo</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>FIRC Institute of Molecular Oncology (IFOM)</institution>, 20139 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="a7">These authors contributed equally to this work</nlm:aff></affiliation></author><author><name sortKey="Morini, Marco Francesco" sort="Morini, Marco Francesco" uniqKey="Morini M" first="Marco Francesco" last="Morini">Marco Francesco Morini</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>FIRC Institute of Molecular Oncology (IFOM)</institution>, 20139 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pitulescu, Mara Elena" sort="Pitulescu, Mara Elena" uniqKey="Pitulescu M" first="Mara Elena" last="Pitulescu">Mara Elena Pitulescu</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine and Faculty of Medicine, University of Münster</institution>, 48149 Münster,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bhat, Ganesh" sort="Bhat, Ganesh" uniqKey="Bhat G" first="Ganesh" last="Bhat">Ganesh Bhat</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>FIRC Institute of Molecular Oncology (IFOM)</institution>, 20139 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nyqvist, Daniel" sort="Nyqvist, Daniel" uniqKey="Nyqvist D" first="Daniel" last="Nyqvist">Daniel Nyqvist</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet</institution>, SE-171 77 Stockholm,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Breviario, Ferruccio" sort="Breviario, Ferruccio" uniqKey="Breviario F" first="Ferruccio" last="Breviario">Ferruccio Breviario</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>FIRC Institute of Molecular Oncology (IFOM)</institution>, 20139 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Conti, Valentina" sort="Conti, Valentina" uniqKey="Conti V" first="Valentina" last="Conti">Valentina Conti</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Division of Regenerative Medicine, Stem Cells and Gene Therapy DIBIT H San Raffaele</institution>, 20132 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Briot, Anais" sort="Briot, Anais" uniqKey="Briot A" first="Anais" last="Briot">Anais Briot</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Molecular, Cell and Developmental Biology, University of California</institution>, 90095 Los Angeles, California,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Iruela Arispe, M Luisa" sort="Iruela Arispe, M Luisa" uniqKey="Iruela Arispe M" first="M. Luisa" last="Iruela-Arispe">M. Luisa Iruela-Arispe</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Molecular, Cell and Developmental Biology, University of California</institution>, 90095 Los Angeles, California,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Adams, Ralf H" sort="Adams, Ralf H" uniqKey="Adams R" first="Ralf H." last="Adams">Ralf H. Adams</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine and Faculty of Medicine, University of Münster</institution>, 48149 Münster,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dejana, Elisabetta" sort="Dejana, Elisabetta" uniqKey="Dejana E" first="Elisabetta" last="Dejana">Elisabetta Dejana</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>FIRC Institute of Molecular Oncology (IFOM)</institution>, 20139 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Department of Biological Sciences, School of Sciences, University of Milan</institution>, 20122 Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The functional diversity of the arterial and venous endothelia is regulated through a complex system of signalling pathways and downstream transcription factors. Here we report that the transcription factor Sox17, which is known as a regulator of endoderm and hemopoietic differentiation, is selectively expressed in arteries, and not in veins, in the mouse embryo and in mouse postnatal retina and adult. Endothelial cell-specific inactivation of Sox17 in the mouse embryo is accompanied by a lack of arterial differentiation and vascular remodelling that results in embryo death <italic>in utero</italic>. In mouse postnatal retina, abrogation of Sox17 expression in endothelial cells leads to strong vascular hypersprouting, loss of arterial identity and large arteriovenous malformations. Mechanistically, Sox17 acts upstream of the Notch system and downstream of the canonical Wnt system. These data introduce Sox17 as a component of the complex signalling network that orchestrates arterial/venous specification.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adams, R H" uniqKey="Adams R">R. H. 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Melton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Claxton, S" uniqKey="Claxton S">S. Claxton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koch, U" uniqKey="Koch U">U. Koch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, H" uniqKey="Han H">H. Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kisanuki, Y Y" uniqKey="Kisanuki Y">Y. Y. Kisanuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cattelino, A" uniqKey="Cattelino A">A. Cattelino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lampugnani, M G" uniqKey="Lampugnani M">M. G. Lampugnani</name></author><author><name sortKey="Orsenigo, F" uniqKey="Orsenigo F">F. Orsenigo</name></author><author><name sortKey="Gagliani, M C" uniqKey="Gagliani M">M. C. Gagliani</name></author><author><name sortKey="Tacchetti, C" uniqKey="Tacchetti C">C. Tacchetti</name></author><author><name sortKey="Dejana, E" uniqKey="Dejana E">E. Dejana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taddei, A" uniqKey="Taddei A">A. Taddei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baluk, P" uniqKey="Baluk P">P. Baluk</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Italie</li><li>Suède</li><li>États-Unis</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Corada, Monica" sort="Corada, Monica" uniqKey="Corada M" first="Monica" last="Corada">Monica Corada</name></noRegion><name sortKey="Bhat, Ganesh" sort="Bhat, Ganesh" uniqKey="Bhat G" first="Ganesh" last="Bhat">Ganesh Bhat</name><name sortKey="Breviario, Ferruccio" sort="Breviario, Ferruccio" uniqKey="Breviario F" first="Ferruccio" last="Breviario">Ferruccio Breviario</name><name sortKey="Conti, Valentina" sort="Conti, Valentina" uniqKey="Conti V" first="Valentina" last="Conti">Valentina Conti</name><name sortKey="Dejana, Elisabetta" sort="Dejana, Elisabetta" uniqKey="Dejana E" first="Elisabetta" last="Dejana">Elisabetta Dejana</name><name sortKey="Dejana, Elisabetta" sort="Dejana, Elisabetta" uniqKey="Dejana E" first="Elisabetta" last="Dejana">Elisabetta Dejana</name><name sortKey="Morini, Marco Francesco" sort="Morini, Marco Francesco" uniqKey="Morini M" first="Marco Francesco" last="Morini">Marco Francesco Morini</name><name sortKey="Orsenigo, Fabrizio" sort="Orsenigo, Fabrizio" uniqKey="Orsenigo F" first="Fabrizio" last="Orsenigo">Fabrizio Orsenigo</name></country><country name="Allemagne"><noRegion><name sortKey="Pitulescu, Mara Elena" sort="Pitulescu, Mara Elena" uniqKey="Pitulescu M" first="Mara Elena" last="Pitulescu">Mara Elena Pitulescu</name></noRegion><name sortKey="Adams, Ralf H" sort="Adams, Ralf H" uniqKey="Adams R" first="Ralf H." last="Adams">Ralf H. Adams</name></country><country name="Suède"><noRegion><name sortKey="Nyqvist, Daniel" sort="Nyqvist, Daniel" uniqKey="Nyqvist D" first="Daniel" last="Nyqvist">Daniel Nyqvist</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Briot, Anais" sort="Briot, Anais" uniqKey="Briot A" first="Anais" last="Briot">Anais Briot</name></noRegion><name sortKey="Iruela Arispe, M Luisa" sort="Iruela Arispe, M Luisa" uniqKey="Iruela Arispe M" first="M. Luisa" last="Iruela-Arispe">M. Luisa Iruela-Arispe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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